2013 Fiscal Year Final Research Report

Increased expression of aryl hydrocarbon receptor in clear cell renal cell carcinoma and infiltrating lymphocytes: Implications for cancer invasion, prognosis and tumor immunity

Research Project

Project/Area Number	24791668
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	Keio University
Principal Investigator	ISHIDA Masaru 慶應義塾大学, 医学部, 共同研究員 (80383876)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	腎細胞癌 / 芳香族炭化水素受容体 / 浸潤 / 発癌
Research Abstract	AhR in RCC was significantly associated with the smoking history, gender and histological grade. The number of AhR-positive TIL was significantly associated with histological grade and pathological T stage. In tumor tissues, the number of T cell was significantly higher than that of B cell. In the patients who have poor prognosis, the number of helper T cell was significantly higher than that of cytotoxic T cell. Furthermore, in those patients AhR-positive TIL and regulatory T cell more infiltrated in tumor adjacent tissues than in tumor tissues. The AhR expression in TIL was a significant predictor for progression free survival. A multivariate analysis revealed that AhR in cancer cells was an independent prognostic factor for the progression free survival and disease specific survival. These results suggest that AhR may be involved in tumor immunity.