2013 Fiscal Year Final Research Report
The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma
| Project/Area Number |
24791671
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Keio University |
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Principal Investigator |
TANAKA Nobuyuki 慶應義塾大学, 医学部, 講師(非常勤) (60445244)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 尿路上皮癌 / 血管新生 / レニンアンギオテンシン |
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| Research Abstract |
Using a multi-institutional and retrospective cohort of patients with upper tract urothelial carcinoma (UTUC) in Japan, we found that the absence of renin-angiotensin system (RAS) inhibitors was significantly associated with disease recurrence following radical nephroureterectomy independent of other clinicopathological parameter, suggesting RAS inhibition might be effective to prevent subsequent relapsing in UTUC. Moreover, immunohistochemical analysis in surgical specimens revealed that the microvessel density in tumors was significantly associated with oncological outcome in UTUC patients, suggesting the importance of its upper modulator of RAS regulation in UTUC.
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[Journal Article] Metastatic Behavior of Upper Tract Urothelial Carcinoma Following Radical Nephroureterectomy : Association with Primary Tumor Location2014
Author(s)
Tanaka N, Kikuchi E, Kanao K, Matsumoto K, Kobayashi H, Ide H, Miyazaki Y, Obata J, Hoshino K, Shirotake S, Akita H, Kosaka T, Miyajima A, Momma T, Nakagawa K, Hasegawa S, Nakajima Y, Jinzaki M, Oya M
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Journal Title
Ann Surg Oncol
Volume: 21
Pages: 1038-45
DOI
Peer Reviewed
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[Journal Article] The Predictive Value of C-reactive Protein for Prognosis in Patients with Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy : A Multi-institutional Study2014
Author(s)
Tanaka N, Kikuchi E, Shirotake S, Kanao K, Matsumoto K, Kobayashi H, Miyazaki Y, Ide H, Obata J, Hoshino K, Hayakawa N, Ito Y, Kosaka T, Kodaira K, Oyama M, Miyajima A, Momma T, Nakagawa K, Ueno M, Oya M
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Journal Title
Eur Urol
Volume: 65
Pages: 227-34
DOI
Peer Reviewed
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[Journal Article] Independent predictors for bladder outcomes after treatment of intravesical recurrence following radical nephroureterectomy in patients with primary upper tract urothelial carcinoma2014
Author(s)
Tanaka N, Kikuchi E, Kanao K, Matsumoto K, Shirotake S, Kobayashi H, Miyazaki Y, Ide H, Obata J, Hoshino K, Hayakawa N, Hagiwara M, Kosaka T, Oyama M, Miyajima A, Momma T, Nakagawa K, Jinzaki M, Hasegawa S, Nakajima Y, Oya M
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Journal Title
Ann Surg Oncol
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Patient characteristics and outcomes in metastatic upper tract urothelial carcinoma after radical nephroureterectomy : the experience of Japanese multi-institutions2013
Author(s)
Tanaka N, Kikuchi E, Kanao K, Matsumoto K, Kobayashi H, Miyazaki Y, Ide H, Obata J, Hoshino K, Shirotake S, Hayakawa N, Kosaka T, Miyajima A, Momma T, Nakagawa K, Hasegawa S, Nakajima Y, Oya M
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Journal Title
BJU Int
Volume: 112
Pages: E28-34
DOI
Peer Reviewed
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[Journal Article] The predictive value of positive urine cytology for outcomes following radical nephroureterectomy in patients with primary upper tract urothelial carcinoma : A multi-institutional study2013
Author(s)
Tanaka N, Kikuchi E, Kanao K, Matsumoto K, Shirotake S, Kobayashi H, Miyazaki Y, Ide H, Obata J, Hoshino K, Hayakawa N, Kosaka T, Oyama M, Miyajima A, Momma T, Nakagawa K, Jinzaki M, Nakajima Y, Oya M
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Journal Title
Urol Oncol
Volume: 32
Pages: 48.e19-26
DOI
Peer Reviewed
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