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2013 Fiscal Year Final Research Report

The possibility of WT1 gene for new therapeutic target in ovarian cancer

Research Project

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Project/Area Number 24791680
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionYamagata University

Principal Investigator

OHTA Tsuyoshi  山形大学, 医学部, 助教 (50375341)

Project Period (FY) 2012-04-01 – 2014-03-31
KeywordsWilms' tumor 1 (WT1) / 卵巣癌 / 腫瘍産生 / VEGF / 血管新生
Research Abstract

In this study, we sought to investigate the effects of WT1 splice variants on tumorigenic activity and survival in an in vivo ovarian cancer model. In mice inoculated intraperitoneally with SKOV3ip1 cells expressing WT1 -17AA/-KTS, disseminated tumor weights and production of ascites were significantly increased compared with those in mice inoculated with cells expressing the control vector. The overall survival in mice with WT1 -17AA/-KTS-expressing cells was significantly shorter than that in mice with control cells. WT1 -17AA/-KTS significantly increased the expression of vascular endothelial growth factor (VEGF) and tumor microvessel density compared with the control. These results indicated that WT1 -17AA/-KTS could enhance tumorigenic activity and could decrease patient survival through up-regulation of VEGF expression in ovarian cancers. The expression of WT1 -17AA/-KTS may induce ovarian cancer cells into a more aggressive phenotype.

  • Research Products

    (9 results)

All 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Non-sex cord-stromal ovarian tumors frequently produce and secrete estrogen inpostmenopausal women : impact on bone metabolism and abnormal endometrialhistology2013

    • Author(s)
      Matsumura S, Ohta T, Takahashi T, Yamazaki T, Takahashi K, Kurachi H
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 98(7) Pages: 2775-82

    • DOI

      10.1210/jc.2013-1267

    • Peer Reviewed
  • [Journal Article] 子宮頸部神経内分泌癌 6 例の解析2013

    • Author(s)
      長谷川 歩美, 太田 剛, 倉智 博久
    • Journal Title

      臨床婦人科産科

      Volume: 68(1) Pages: 165-170

    • URL

      http://search.jamas.or.jp/index.php

    • Peer Reviewed
  • [Journal Article] Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through theblockage of hypoxia-inducible factor-1α in human ovarian cancer cells2012

    • Author(s)
      Ohta T, Takahashi T, Shibuya T, Amita M, Henmi N, Takahashi K, Kurachi H
    • Journal Title

      Cancer Biol Ther

      Volume: 13(1) Pages: 25-33

    • DOI

      10.4161/cbt.13.1.18440

    • Peer Reviewed
  • [Journal Article] Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells2012

    • Author(s)
      Ohta T, Ohmichi M, Shibuya T, Takahashi T, Tsutsumi S, Takahashi K, Kurachi H
    • Journal Title

      Cancer Biol Ther

      Volume: 13(6) Pages: 408-16

    • DOI

      10.4161/cbt.19292

    • Peer Reviewed
  • [Journal Article] 婦人科腫瘍との鑑別が困難であったGIST の 2 例2012

    • Author(s)
      松村創平, 太田 剛, 水谷雅臣, 蜂谷 修, 木村 理, 菅井幸雄, 高橋一広, 倉智博久
    • Journal Title

      臨床婦人科産科

      Volume: 66(9) Pages: 799-802

    • URL

      http://search.jamas.or.jp/index.php

    • Peer Reviewed
  • [Presentation] Evaluation of preventive methods for the symptomatic pulmonary thromboembolism by postoperative anticoagulant therapy in VTE high risk patients with gynecologic malignancy2013

    • Author(s)
      Takahashi T, Seino M, Ohta T, Sudo T, Ishida H, Kurachi H
    • Organizer
      第65回日本産科婦人科学会
    • Place of Presentation
      ホテル札幌芸文館(札幌市)
    • Year and Date
      20130510-12
  • [Presentation] The role of YY1 in paclitaxel-induced cytotoxicity in epithelial ovarian cancer2012

    • Author(s)
      Ohta T, Ota T, Chien J, Shridhar V, Kurachi H
    • Organizer
      AACR
    • Place of Presentation
      McCormic Place in Chicago, IL, USA
    • Year and Date
      20120331-0404
  • [Book] [子宮体がん診療アップデート] 診断のトピックス 子宮体がん発症のリスク因子2013

    • Author(s)
      竹原 功, 太田 剛, 倉智 博久
    • Total Pages
      440-446
    • Publisher
      臨床婦人科産科
  • [Remarks]

    • URL

      http://www.id.yamagata-u.ac.jp/ObGyn/

URL: 

Published: 2015-06-25  

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