2013 Fiscal Year Final Research Report
Adipocytokines and follicular development
| Project/Area Number |
24791681
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | アディポサイトカイン / 卵胞体外培養 / インスリン抵抗性改善薬 |
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| Research Abstract |
Polycystic ovary syndrome (PCOS) is a common ovulatory disorder in young women. We examined to clarify the pathogenesis of PCOS by using an in vitro mouse preantral follicle culture system. TNF-alpha is an aipocytokine, which raise insulin resistance. TNF-alpha directly inhibited follicular development. On the other hand, insulin-sensitizing drugs restored the TNF-alpha-mediated inhibition of follicular development.
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