2013 Fiscal Year Final Research Report
Effects of metformin in combination with chemotherapeutic agents on endometrial carcinoma cells
| Project/Area Number |
24791686
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Chiba University |
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Principal Investigator |
UEHARA Takashi 千葉大学, 医学(系)研究科(研究院), 助教 (70568659)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 婦人科腫瘍 / 子宮体癌 / メトホルミン / 抗がん薬 |
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| Research Abstract |
We assessed the anti-cancer effect of metformin in combination with chemotherapeutic agent (cisplatin) on endometrial cancer cell line. Metformin inhibited endometrial cancer cell proliferation, and potentiated the anti-cancer effect of cisplatin on endometrial cancer cell line. These effects were attenuated under hypoxic condition compared to normoxic condition, though were not antagonized.
Administration of metformin with cisplatin does not affect the efficacy of cisplatin, and metformin without cisplatin inhibits cancer cell proliferation. Administration of metformin in combination with cisplatin on the treatment of endometrial cancer probably enhances the therapeutic effects.
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[Journal Article] Incidence, Risk Factors and Treatment Outcomes of Extravasation of Cytotoxic Agents in an Outpatient Chemotherapy Clinic2014
Author(s)
Sakaida Emiko, Sekine Ikuo, Iwasawa Shunichiro, Kurimoto Ryota, Uehara Takashi, Ooka Yoshihiko, Akanuma Naoki, Tada Yuji, Imai Chiaki, Oku Tomoko, Takiguchi Yuichi
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Journal Title
Jpn J Clin Oncol
Volume: 44(2)
Pages: 168-71
Peer Reviewed
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