2014 Fiscal Year Final Research Report
Protective effect of dienogest on chemotherapy-induced reduced fertility in female rats.
| Project/Area Number |
24791695
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ORISAKA Makoto 福井大学, 医学部附属病院, 講師 (80324143)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ジェノゲスト / 抗癌剤 / ラット / 卵巣機能保護 / 妊孕性 |
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| Outline of Final Research Achievements |
We examined with a female rat model whether and how dienogest modulates reduced fertility following exposure to gonadotoxic chemotherapy. Female rats were administered cyclophosphamide with or without GnRH agonist and dienogest, and the numbers of follicle in the ovaries were counted histologically. Rats treated with these drugs were also mated with male rats to evaluate their fertility and pregnancy outcomes. Cyclophosphamide significantly reduced the number of primordial follicles, whereas dienogest suppressed depletion of primordial follicle pool induced by chemotherapy. Although the rats exposed to cyclophosphamide alone failed to deliver live births, co-treatment with dienogest improved the pregnancy outcomes. The protective effect of dienogest was comparable to that of GnRH agonist. The results suggest that the co-administration with dienogest may be a useful strategy in preserving ovarian function and fertility in premenopausal women facing gonadotoxic chemotherapy.
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| Free Research Field |
産科婦人科学
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