FGFR2IIIc related to carcinogenesis and as a potential molecular target for endometrioid adenocarcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791725
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Nippon Medical School
• Principal Investigator: PENG Wei-Xia 日本医科大学, 医学部, 講師 (00535700)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 類内膜腺癌 / FGFR2 IIIｃ / carcinogenesis

Outline of Final Research Achievements

We identified roles for Fibroblast Growth Factor Receptor 2 (FGFR2)isoform IIIc in EEC carcinogenesis and demonstrated its diagnostic and prognostic values in EEC. Compared to high expression in atypical hyperplasia, Grade 1 (G1), and Grade 2 (G2) EEC tissues, Grade 3 (G3) EEC tissue showed low FGFR2IIIc expression (P <0.05). These results suggest that altered FGFR2IIIc expression plays an important role in EEC carcinogenesis. Some G3 EECs may develop through different carcinogenic processes than G1 and G2 EECs.
With the aim of identifying diagnostic and treatment biomarkers for EEC, we analyzed protein expression of EECs using proteomix. Although we could not identify high FGFR2IIIc expression in EEC tissues, 14 proteins showed upregulation in G3 EECs comapared to G1 and G2 EECs. These results may help in the identification of novel potential therapeutic target in EECs.

Free Research Field

婦人科腫瘍