The role of cleaved prolactin in pregnancy complicated with heart disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791734
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KAMIYA Chizuko 独立行政法人国立循環器病研究センター, 病院, 医師 (10551301)
• Co-Investigator(Renkei-kenkyūsha): IKEDA Tomoaki 三重大学医学部, 産科婦人科学教室, 教授 (80202894) ; MICHIYO Ishida 明治大学, 農学部生命科学科生体機構学研究室, 特任講師 (20445860)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 循環器疾患 / 妊娠 / プロラクチン

Outline of Final Research Achievements

The aim of the study was to analyze the role of cleaved prolactin, known as an antiangiogenic agent, in pregnancy complicated with heart disease, by both clinical and basic research. The amount of cleaved prolactin during antepartum and postpartum was significantly increased in women with heart disease compared with those in the healthy controls. Postpartum women with heart disease who did breast feeding tended to experience a cardiovascular event more often than those who did not breast feed.
The cardiac weight of model mice was increased the most during lactation. Histological stain revealed that cleaved prolactin existed in both capillary vessels and cardiomyocytes.

Free Research Field

循環器内科