2014 Fiscal Year Final Research Report
Development of new treatments for nasal diseases through novel target molecules
| Project/Area Number |
24791742
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 慢性副鼻腔炎 / アレルギー性鼻炎 / ペンドリン / ペリオスチン |
|---|
| Outline of Final Research Achievements |
Several factors contribute to pathologies such as excessive mucus production and mucosal edema, leading to nasal discharge and obstruction in inflammatory nasal disorders. These pathological conditions might be precipitated by the actions of molecules such as pendrin and periostin. Production of these molecules is induced by IL-13 in airway epithelial cell cultures. Production of these molecules is upregulated in inflammatory nasal disorders.
We also studied the correlation between serum periostin concentration and severity of chronic sinusitis. Periostin may be employed as a biomarker of disease activity and severity of inflammatory nasal disorders.
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| Free Research Field |
鼻科学
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