Prediction of response to Docetaxel in head and neck squamous cell carcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791750
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: OMURA Go 東京大学, 医学部附属病院, 助教 (00601139)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 下咽頭癌 / 予後因子 / Focal Adhesion Kinase

Outline of Final Research Achievements

We could not evaluate the CYP3A4 expression for hypopharyngeal cancer (HPC) treated with induction TPF regimen, because of technical problem. Therefore, we changed the contents of this study. Focal adhesion kinase (FAK) plays an important role in tumor metastasis. We evaluated the significance of FAK expression in surgically treated HPC patients. FAK expression status was retrospectively evaluated using immunohistochemistry. FAK-positive patients displayed significantly worse disease-specific survival than FAK-negative patients. Furthermore, FAK positivity significantly correlated with the number of metastatic lymph nodes, and FAK-positive patients displayed a higher incidence of distant metastases. In conclusion, upregulated FAK expression correlates with poor prognosis and tumor dissemination in surgically treated HPC patients.

Free Research Field

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