converging area underlying right or left localization of odor sources

2013 Fiscal Year Final Research Report

• Project/Area Number: 24791753
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: KIKUTA Shu 東京大学, 保健・健康推進本部, 助教 (00555865)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 嗅覚 / 嗅上皮障害

Research Abstract

The mammalian individual sensory systems integrate two right and left sensory inputs and generate accurate spatial representation of environmental cues. In olfactory systems, odors are inhaled through the nostrils into two segregated nasal passages and processed by two, right and left olfactory pathways. Anterior olfactory nucleus (AON) of the adult rat olfactory cortex receives axonal inputs from ipsi-lateral olfactory bulb and also receives inputs from contra-lateral olfactory cortex, suggesting binasal converging interaction from ipsi-lateral and contra-lateral olfactory epithelia (OEs). We showed that ipsi-excitatory and contra-inhibitory converging inputs (E-I type AON neurons) were selectively located in the AON Pars Externa (AONpE), the rostro-lateral subregion of the AON.

Research Products

• [Journal Article] Odorant response properties of individual neurons in an olfactory glomerular module Neuron (2013)
  • Author(s): Shu Kikuta, Max Fletcher, Ryota Homma, Tatsuya Yamasoba, Shin Nagayama
  • Volume: vol.77
  • Pages: 1122-1135
  • DOI: 10.1016/j.neuron.2013.01.022
  • Peer Reviewed
• [Presentation] 嗅覚入力依存的な嗅上皮障害後の再生 (2013)
  • Author(s): 菊田周, 坂本幸士, 近藤健二, 金谷佳織, 岩村均, 鈴川佳吾, 平野真希子, 西嶌大宜, 籠谷領二, 森憲作, 山岨達也
  • Organizer: 第52回日本鼻科学会総会
  • Place of Presentation: 福井県福井市
  • Year and Date: 20130926-28
• [Presentation] Olfactory sensory input-dependent incorporation of newly generated olfactory sensory neurons following injury (2013)
  • Author(s): Shu Kikuta, Takashi Sakamoto, Kenji Kondo, Hitoshi Iwamura, Kaori Kanaya, Keigo Suzukawa, Kensaku Mori, and Tatsuya Yamasoba
  • Place of Presentation: 東京都新宿区
  • Year and Date: 20130829-31
• [Presentation] Neuronal responses for odor information processing in the anterior olfactory cortex (2013)
  • Author(s): Shu Kikuta
  • Organizer: 20th World Congress of the International Federation of Oto-Rhino-Laryngological Societies
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20130601-05
• [Presentation] マウス嗅球糸球体層細胞と嗅神経の匂い分子受容範囲の比較 (2013)
  • Author(s): 菊田周, 永山晋, 山岨達也
  • Organizer: 第114回日本耳鼻咽喉科学会総会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 20130515-15
• [Presentation] 単一糸球体に属する嗅球細胞群の匂い応答 (2012)
  • Author(s): 菊田周, 山岨達也
  • Organizer: 第46回日本味と匂い学会
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 20121003-05
• [Presentation] 嗅上皮傷害後の再生過程における嗅覚入力の重要性 (2012)
  • Author(s): 菊田周, 坂本幸士, 近藤健二, 金谷佳織, 馬場信太郎, 平野真希子, 森憲作
  • Organizer: 第51回日本鼻科学会
  • Place of Presentation: 千葉県幕張市
  • Year and Date: 20120927-29
• [Presentation] マウス単一糸球に属する僧帽細胞群の異なる匂い応答 (2012)
  • Author(s): 菊田周, 山岨達也, Wei R.Chen
  • Organizer: 第113回日本耳鼻咽喉科学会総会
  • Place of Presentation: 新潟県新潟市
  • Year and Date: 20120510-12
• [Presentation] Distinct Odor Representation of Individual Neurons within a Single Glomerulus Module in the Mouse Main Olfactory Bulb (2012)
  • Author(s): Shu Kikuta, Tatsuya Yamasoba, Wei R. Chen
  • Organizer: 第14回日韓耳鼻咽喉科学会
  • Place of Presentation: 京都府京都市
  • Year and Date: 20120412-14