2013 Fiscal Year Final Research Report
Analysis of sensitization and onset of allergic rhinitis
| Project/Area Number |
24791761
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | アレルギー性鼻炎 |
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| Research Abstract |
We measured Japanese cedar (JC) specific IgE in serum about 3453 subjects and found that 57.5% of these subjects possess JC-specific IgE. Among them who have high-JC-specific IgE, 72.2% of these subjects show allergic rhinitis (AR) related symptoms during JC pollen, while the other subjects had not experienced any AR related symptoms. These subjects are only sensitized subjects. We studied the levels of chemokines related to AR among non-atopic subjects, sensitized subjects, and patients with seasonal allergic rhinitis by JC pollen in order to predict onset of AR. We also performed gene expression analysis and found that Cystatin SN (CST1) was a candidate gene that affect sensitization and onset of AR.
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Research Products
(20 results)
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[Journal Article] Genome-Wide Association Study for Levels of Total Serum IgE Identifies HLA-C in a Japanese Population2013
Author(s)
Yatagai Y, Sakamoto T, Masuko H, Kaneko Y, Yamada H, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Imoto Y, Tokunaga T, Fujieda S, Konnno S, Nishimura M, Hizawa N
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Journal Title
PLoS One
Volume: 8(12)
Pages: e80941
DOI
Peer Reviewed
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[Journal Article] Expression and Function of Allergin-1 on Human Primary Mast Cells2013
Author(s)
Nagai K, Tahara-Hanaoka S, Morishima Y, Tokunaga T, Imoto Y, Noguchi E, Kanemaru K, Imai M, Shibayama S, Hizawa N, Fujieda S, Yamagata K, Shibuya A
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Journal Title
PLoS One
Volume: 7;8
Pages: e76160
DOI
Peer Reviewed
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[Journal Article] Cystatin SN Upregulation in Patients with Seasonal Allergic Rhinitis2013
Author(s)
Imoto Y, Tokunaga T, Matsumoto Y, Hamada Y, Ono M, Yamada T, Ito Y, Arinami T, Okano M, Noguchi E, Fujieda S
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Journal Title
PLoS One
Volume: 12;8
Pages: e67057
DOI
Peer Reviewed
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[Journal Article] A critical role of IL-33 in experimental allergic rhinitis2012
Author(s)
Haenuki Y, Matsushita K, Yumikura S, Ishii KJ, Kawagoe T, Imoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T
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Journal Title
J Allergy Clin Immunol
Volume: 130
Pages: 184-94
DOI
Peer Reviewed
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[Journal Article] Generation of induced pluripotent stem cells from human nasal epithelial cells using a sendai virus vector2012
Author(s)
Ono M , Hamada Y , Horiuchi Y , Matsuo-Takasaki M , Imoto Y , Satomi K , Arinami T , Hasegawa M , Fujioka T , Nakamura Y , Noguchi E
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Journal Title
PLoS One
Volume: 7(8)
Pages: e42855
DOI
Peer Reviewed
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