Can overexpression of galectin-3 in the thyroid induce thyroid carcinoma with the transgenic mouse model?

2015 Fiscal Year Final Research Report

• Project/Area Number: 24791775
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Osaka University
• Principal Investigator: Nakahara Susumu 大阪大学, 医学(系)研究科(研究院), 助教 (20625107)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: ガレクチンー３ / トランスジェニックマウス / 甲状腺癌

Outline of Final Research Achievements

We developed the transgenic mice that overexpressed galectin-3 in the thyroid tissue, so that the role of galectin-3 overexpression in the thyroid carcinoma would be elucidated. We removed the thyroids of the transgenic mice at the age of 3-month and observed them under a microscope. There were no carcinomas or abnormalities in the thyroid tissue. This result indicates that overexpression of galectin-3 would not be the important factor for carcinogenesis but arise on the result after thyroid carcinoma is occurred, whereas we cannot conclude it with relatively short observation period.

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