2013 Fiscal Year Final Research Report
Base study for the radical treatment of the cedar pollinosis by the identification of the Tr1 instruction cedar pollen epitope
| Project/Area Number |
24791780
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
NODA Yohei 岡山大学, 大学病院, 助教 (00587404)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | スギ花粉症 / 健常人 / IL-10 / 制御性細胞 / ペプチド |
|---|
| Research Abstract |
We sought to determine the cellular responses to Cry j 1, the major allergen of Japanese cedar pollen, in healthy Japanese. Peripheral blood mononuclear cells produced a substantial amount of IL-10 in response to Cry j 1. We synthesized 45 overlapping peptide with 15 amino acids from N-terminal of Cry j 1. However, we could not find a particular peptide in which PBMCs from healthy subjects produced IL-10. In addition, we found that LAG-1 and CD201 positive population in CD4 positive cells were increased in response to Cry j 1, suggesting that Tr1 is induced in healthy subject following the exposure to Japanese cedar pollen
|
