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2013 Fiscal Year Final Research Report

The mechanism of preseasonal prophylactic treatment with steroid nasal spray on pollinosis

Research Project

  • PDF
Project/Area Number 24791783
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokushima

Principal Investigator

KITAMURA Yoshiaki  徳島大学, 大学病院, 講師 (60380028)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords鼻科学
Research Abstract

Preseasonal prophylactic treatment with steroid nasal spray is more effective than on-seasonal administration to patients with pollinosis in reducing nasal symptoms during the peak pollen period by suppressing histamine H1 receptor gene expression in the nasal mucosa.

  • Research Products

    (10 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] アレルギー性鼻炎におけるヒスタミンH1受容体遺伝子発現亢進の分子機構とその制御2014

    • Author(s)
      北村嘉章, 水口博之, 福井裕行, 武田憲昭
    • Journal Title

      耳鼻臨床

      Volume: 107 (4) Pages: 261-270

  • [Journal Article] 【アレルギー性鼻炎の発症メカニズム】アレルギー性鼻炎におけるヒスタミンH1 受容体の役割2014

    • Author(s)
      北村嘉章, 水口博之, 福井裕行, 武田憲昭
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 61(3) Pages: 274-281

  • [Journal Article] Combination of leukotoriene receptor antagonist with antihistamine has an additive suppressive effect on the up-regulation of H1-receptor mRNA in the nasal mucosa of toluene 2, 4-diisocyanate-sensitized rat2013

    • Author(s)
      Kuroda W, Kitamura Y, Mizuguchi H, Miyamoto Y, Kalubi B, Fukui H, Takeda N
    • Journal Title

      J Pharmacol Sci

      Volume: 122 Pages: 55-58

    • DOI

      10.1254/jphs.12250SC

    • Peer Reviewed
  • [Journal Article] Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen2012

    • Author(s)
      Kitamura Y, Mizuguchi H, Ogishi H, Kuroda W, Hattori M, Fukui H, Takeda N
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Pages: 434-8

    • DOI

      10.3109/00016489.2011.644804

    • Peer Reviewed
  • [Presentation] スギ花粉曝露によるスギ花粉症患者鼻粘膜ヒスタミンH1 受容体の役割遺伝子発現の亢進に対する抗ヒスタミン薬の効果2013

    • Author(s)
      北村嘉章
    • Organizer
      第63回日本アレルギー学会秋季学術大会
    • Place of Presentation
      ホテルニューオータニ, (東京都)
    • Year and Date
      20131128-30
  • [Presentation] The effect of antihistamine on up-regulation of histamine H1 receptor mRNA in patients with pollinosis induced by the artificial exposure of cedar pollen2013

    • Author(s)
      Kitamura Y
    • Organizer
      16th Asian Research Symposium in Rhinology
    • Place of Presentation
      Keio Plaza Hotel, Tokyo
    • Year and Date
      20130829-31
  • [Presentation] アレルギー性鼻炎の発症メカニズムと治療, ヒスタミンH1 受容体の役割2013

    • Author(s)
      北村嘉章
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      パシフィコ横浜, (神奈川県横浜市)
    • Year and Date
      20130511-12
  • [Presentation] スギ花粉症に対する鼻噴霧ステロイド薬の初期療法とH1 受容体遺伝子発現への効果2013

    • Author(s)
      北村嘉章
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷市芸文館, (岡山県倉敷市)
    • Year and Date
      20130207-09
  • [Presentation] ヒスタミンH1 受容体拮抗薬はほんとうにinverse agonist か?2013

    • Author(s)
      北村嘉章
    • Organizer
      第25回日本第17回日本ヒスタミン学会
    • Place of Presentation
      松江テルサ, (島根県松江市)
    • Year and Date
      2013-11-22
  • [Presentation] 鼻噴霧ステロイド薬のヒスタミンH1 受容体遺伝子発現への効果2012

    • Author(s)
      北村嘉章
    • Organizer
      第51回日本鼻科学会総会
    • Place of Presentation
      幕張メッセ, (千葉県千葉市)
    • Year and Date
      20120927-29

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Published: 2015-06-25  

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