2014 Fiscal Year Final Research Report
Effects of nerve-muscle pedicle on immobile rat vocal folds in the presence of partial innervation.
| Project/Area Number |
24791789
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kumamoto University |
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Principal Investigator |
AOYAMA Takashi 熊本大学, 医学部附属病院, 助教 (70600170)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ansa cervicalis nerve / dual reinnervation / nerve-muscle pedicle |
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| Outline of Final Research Achievements |
OBJECTIVES: We investigated whether implantation of an ansa cervicalis nerve (ACN)-muscle pedicle into the thyroarytenoid (TA) muscle is efficacious in the presence of partial recurrent laryngeal nerve (RLN) innervation.METHODS:We studied a total of 36 rats. Twelve of the rats served as positive and negative control animals. In the remaining 24 rats, the left RLN was transected, a 1-mm piece of nerve was removed, and the stumps were abutted in silicone tubes (STs), inducing partial RLN regeneration. Twelve of the ST-treated rats underwent this procedure alone, and the other 12 rats had a nerve-muscle pedicle (NMP) implanted into the left TA muscle 5 weeks after ST treatment. At 15 weeks, reinnervation was assessed by histologic evaluation of the TA muscle and by electromyography with stimulation of the RLNs and ACNs.CONCLUSIONS:In rats, NMP implantation is efficacious for reducing atrophic changes in the TA muscle in the presence of partial RLN innervation.
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| Free Research Field |
Laryngology
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