2013 Fiscal Year Final Research Report
Leukotriene receptor variation and it's role in intractable eoshinophilic rhino sinusitis.
| Project/Area Number |
24791791
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kagoshima University |
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Principal Investigator |
OHORI Junichiro 鹿児島大学, 医学部・歯学部附属病院, 講師 (90507162)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 好酸球 / 上皮 / VEGF / ロイコトリエン |
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| Research Abstract |
In order to investigate the role of cysteinyl leukotriene receptor 2 (CysLT2R) in eoshinophilic rhino sinusitis, the production of VEGF from Epithelial cells, the expression of CysLT2R on eosinophil, and the interaction between epithelial cells and eosinophil were examined. It was observed that the autocrine effect in VEGF production on the epithelial cell of nasal mucosa. The expression of CysLT2R was higher than that of CysLT1R on eosinophil. Further, the accentuation of VEGF production was observed in coculture of epithelial cells and eosinophils. These data suggested that CysLT2R and VEGF were one of the couse regarding the refractory pathology of eosinophilic rhino sinusitis.
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