2013 Fiscal Year Final Research Report
Tracheal regeneration using fibroblast growth factor
| Project/Area Number |
24791796
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
TANI Akiko 福島県立医科大学, 医学部, 助手 (30554430)
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| Co-Investigator(Renkei-kenkyūsha) |
TADA Yasuhiro 福島県立医科大学, 医学部, 講師 (70363760)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 気管粘膜再建 / ビトリゲル / 線維芽細胞増殖因子 / コラーゲンスポンジ |
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| Research Abstract |
In this study, the effectiveness of our scaffold with application of basic fibroblast growth factor(b-fgf) was investigated. Three types of scaffold were made: no b-FGF, 10ng b-FGF, and 100ng b-FGF. At 7,14 and 28 days after implantation in rats, the trachea were removed and histologically evaluated. The regeneration of mucosal epithelium and the subepithelial layer was evaluated.
Our technique for tracheal reconstruction affords a feasible approach for accelerating the regeneration of the intraluminal surface and subepithelial layer of tracheal tissue.
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