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2014 Fiscal Year Final Research Report

Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma

Research Project

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Project/Area Number 24791801
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionWakayama Medical University

Principal Investigator

TAMAGAWA SHUNJI  和歌山県立医科大学, 医学部, 助教 (40543781)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords頭頸部癌 / 転移 / microRNA
Outline of Final Research Achievements

Epithelial-mesenchymal-transition (EMT) is a critical step in tumor invasion and metastasis, while its fate is mainly defined by the balanced expression between the miR-200 family and ZEB transcription factors.
In this study, we observed a reciprocal correlation between miR-200c/mir-141 and ZEB1, as well as between ZEB2 and E-cadherin expression in a panel of 13 head and neck squamous cell carcinoma (HNSCC) cell lines. We also confirmed that the enforced expression of miR-200c and miR-141 significantly reduced the migration capacity of HNSCC cells.

Free Research Field

頭頸部癌

URL: 

Published: 2016-06-03  

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