2013 Fiscal Year Final Research Report

Effects of deafness genes on exercise and vestibular function

Research Project

Project/Area Number	24791807
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Juntendo University
Principal Investigator	KASAI Misato 順天堂大学, 医学部, 助教 (70549279)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	先天性難聴 / 遺伝子変異 / 平衡機能障害 / コネキシン26遺伝子 / 運動機能 / 平衡失調遺伝子
Research Abstract	It is well known that the fundamental cause responsible for congenital deafness is brought about by the gene mutations. Furthermore, deafened subjects also suffer from disequilibrium. My previous study suggested that the gene of connexin26 (GJB2), the most prevalent form of deafness genes, influenced vestibular system as well auditory function. In the present study, I aimed to resolve the underlying mechanism pf the vestibular function on the basis of objective evaluation of both excise and vestibular function in addition to the analysis of multiple deafness genes, which may be defined as the imbalance gene.