The role of Th9 cells in the airway inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791817
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: SAEKI Mayumi 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員 (00462771)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アレルギ / アレルギー性鼻炎 / 気管支喘息 / Th2細胞 / Th9細胞

Outline of Final Research Achievements

We analyzed the role of Th9 cells in upper and lower airway inflammation using adoptive transfer models. Both Th2 cells and Th9 cells induce eosinophil accumulation in the lung and airway hyperresponsiveness (AHR) to the inhaled methacholine in bronchial asthma model, and also induce eosinophil accumulation in the nasal cavity and sneezing responses in alelrgic rhinitis model. Th2-induced AHR was abolished by eosinophil deficiency. In contrast, Th9-induced AHR is hardly affected by eosinophil deficiency.

Free Research Field

アレルギー学