2014 Fiscal Year Final Research Report
Development of vaccination for head and neck cancer utilizing antigen presentation by autophagy
| Project/Area Number |
24791820
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 腫瘍免疫 / 頭頸部癌 / autophagy / LC3 / TIL / HLA / 免疫組織化学 |
|---|
| Outline of Final Research Achievements |
Autophagy is an endogenous process that degrades bulk proteins and organelles to maintain energy homeostasis under cellular stress and nutrient starvation. To explore the association between autophagy and anti-tumor immune responses, we investigated the expression of 3 autophagy-related proteins, HLA molecules and infiltration of 3 kinds of immune cells in 74 patients with oral squamous cell carcinoma in relation to various clinicopathological parameters.
Interestingly, autophagy was significantly associated with lymphocyte infiltrations and HLA expressions. Meanwhile, several unfavorable clinicopathological parameters including short overall survival significantly correlates with autophagy. Autophagy is likely to actively mobilize immune cells toward cancer bed and increase tumor antigenicity, while autophagy also relates to malignant potentials and unfavorable prognosis. This results was published in Cancer Science, in addition to other 4 publications.
|
| Free Research Field |
腫瘍免疫
|
