2014 Fiscal Year Final Research Report
VEGF-C, a lymphangiogenic factor, and its receptor system in pterygium
| Project/Area Number |
24791824
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | VEGF-C / 翼状片 |
|---|
| Outline of Final Research Achievements |
In this study, there were many D2-40, a marker for lymphatic vessels, positive cells beneath the epithelium in human pterygium. D2-40-positive cells were consistent with lymphatic endothelial cells. A few lymphatic vessels were noted in the normal conjunctiva. Quantitative analyses revealed that lymphatic densities were significantly greater in pterygium than normal conjunctiva. Moreover, VEGFR-3 immunoreactivity was detected in the lymphatic vessels as well. We further analyzed the mechanisms underlying the induction of VEGF-C. In this study, VEGF-C secretion was induced 48 hours after serum starvation in cultured conjunctival epithelial cells. VEGF-C secretion was further stimulated 48 hours after treatment with interleukin 1beta, an inflammatory cytokine.
|
| Free Research Field |
翼状片
|
