2014 Fiscal Year Final Research Report
Efficacy of naturally-derived anti-oxidant pigments on uveitis model
| Project/Area Number |
24791826
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
|
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | エキノクローム / ぶどう膜炎 |
|---|
| Outline of Final Research Achievements |
Lewis rats were treated with 0.1, 1.0, or 10mg/kg of echinochrome systemically. Then, lipopolysaccharide (LPS) was injected into rats to induce endotoxin-induced uveitis (EIU). The numbers of aqueous cells, protein levels, and TNF-alpha concentrations were significantly decreased in echinochrome-treated rats compared with untreated rats in 24 hours. It was in a dose-dependent decrease.
Immunohistochemical examination showed that reactive oxygen species (ROS) and NF-kappaB signals were decreased in iris/ciliary body.
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| Free Research Field |
眼科学
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