2013 Fiscal Year Final Research Report
New regulating factor of retinal circulation and establishment of treatment of diabetic retinopathy
| Project/Area Number |
24791828
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
OMAE Tsuneaki 旭川医科大学, 医学部, その他 (30451470)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 網膜循環 |
|---|
| Research Abstract |
We showed that adiponectin, an important adipocytokine secreted by adipocytes, elicits mainly endothelium-dependent dilation of the retinal arterioles. Furthermore, there appears to e a positive relationship between plasma concentration of adiponectin and retinal blood flow in early-stage diabetic retinopathy in patients with type 2 diabetes mellitus. Because, our previous clinical study found that RBF is impaired in early-stage diabetic retinopathy in patients with type 2 diabetes mellitus, it is likely that a decreased serum adiponectin level may impair the RBF, resulting in development of retinopathy, in patients with type 2 diabetes mellitus. therapeutic interventions that enhance the actions of adiponectin may lead to a novel potential treatment.
|
