2014 Fiscal Year Final Research Report
Role of antioxidant enzyme in inherited retinal degeneration
| Project/Area Number |
24791837
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OBATA Ryo 東京大学, 医学部附属病院, 助教 (80625434)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 網膜変性 / 抗酸化酵素 |
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| Outline of Final Research Achievements |
A lot of materials were reported as candidates for antioxidant therapy of hereditary retinal dystrophy. Since glutathione peroxidase 4 (GPx4), one of the antioxidant enzymes, was found essential for maturation of photoreceptor cells recently, we studied the role of GPx4 on hereditary. As a result GPx4 was associated with progression of retinal atrophy in a murine model of inherited retinal degeneration. Therefore, GPx4 was suggested to be a novel candidate of the target for antioxidant therapy against inherited retinal degeneration.
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| Free Research Field |
網膜
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