2013 Fiscal Year Final Research Report
Therapeutic potential of semaphorin 3E for the treatment of choroidal neovascularization
| Project/Area Number |
24791847
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
OISHI Akio 京都大学, 医学(系)研究科(研究院), 助教 (50572955)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 脈絡膜新生血管 / semaphorin3E / plexinD1 |
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| Research Abstract |
We performed the study to investigate the effects of Semaphorin3E (Sema3E)/PlexinD1 signal in the development of choroidal neovascularization (CNV) and explore the therapeutic potential of the pathway. We used a laser-induced CNV model in mouse. The presence of PlexinD1 was confirmed immunohistochemically in the endothelial cells of CNV. Intravitreal injection of recombinant Sema3E decreased the CNV size in a dose-dependent manner. This inhibitory effect of Sema3E in the formation of CNV was canceled in the PlexinD1 knockout mice. These results indicate that Sema3E-PlexinD1 signal is involved in the development of CNV and stimulation of the pathway has the therapeutic potential for CNV.
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[Journal Article] LAPTOP Study : A 24-Month Trial of Verteporfin Versus Ranibizumab for Polypoidal Choroidal Vasculopathy2014
Author(s)
Oishi A, Miyamoto N, Mandai M, Honda S, Matsuoka T, Oh H, Kita M, Nagai T, Bessho N, Uenishi M, Kurimoto Y, Negi A
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Journal Title
Ophthalmology
Volume: (in press)
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[Journal Article] Vascular Endothelial Growth Factor Gene and the Response to Anti-Vascular Endothelial Growth Factor Treatment for Choroidal Neovascularization in High Myopia2014
Author(s)
Miyake M, Yamashiro K, Akagi-Kurashige Y, Kumagai K, Nakata I, Nakanishi H, Oishi A, Tsujikawa A, Yamada R, Matsuda F, Yoshimura N
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Journal Title
Ophthalmology
Volume: 121(1)
Pages: 225-33
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[Journal Article] Nagahama Study Group. Association between the cholesteryl ester transfer protein gene and polypoidal choroidal vasculopathy2013
Author(s)
Nakata I, Yamashiro K, Kawaguchi T, Gotoh N, Nakanishi H, Akagi-Kurashige Y, Miyake M, Tsujikawa A, Oishi A, Saito M, Iida T, Yamada R, Matsuda F, Yoshimura N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: (in press)
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[Journal Article] Comparison of the effect of ranibizumab and verteporfin for polypoidal choroidal vasculopathy : 12-month LAPTOP study results2013
Author(s)
Oishi A, Kojima H, Mandai M, Honda S, Matsuoka T, Oh H, Kita M, Nagai T, Fujihara M, Bessho N, Uenishi M, Kurimoto Y, Negi A
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Journal Title
Am J Ophthalmol
Volume: 156(4)
Pages: 644-51
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[Journal Article] Focal choroidal excavation in eyes with central serous chorioretinopathy2013
Author(s)
Ellabban AA, Tsujikawa A, Ooto S, Yamashiro K, Oishi A, Nakata I, Miyake M, Akagi-Kurashige Y, Ueda-Arakawa N, Arichika S, Yoshitake S, Takahashi A, Yoshimura N
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Journal Title
Am J Ophthalmol
Volume: 156(4)
Pages: 673-83
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[Journal Article] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population2012
Author(s)
Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanshi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 53
Pages: 794-798
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