2013 Fiscal Year Final Research Report
investigation of novel classificaitons of diabetic macular edema using self-organizing map
| Project/Area Number |
24791849
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
MURAKAMI Tomoaki 京都大学, 医学(系)研究科(研究院), 助教 (50549095)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 糖尿病黄斑浮腫 / 漿液性網膜剥離 / 嚢胞様腔 / 血管透過性亢進 / 黄斑部視細胞障害 / 自己組織化マップ |
|---|
| Research Abstract |
I investigated the pathogenesis of diabetic macular edema (DME) using optical coherence tomography (OCT). I established a novel methods for the segmentation of inner and outer retinal layers, following the measurements of these layers. Second, I performed the comparative study about the mechanisms of distrubance in foveal photoreceptor, and found the association between hyperreflective foci, external limiting membrane, the junction of inner and outer segments of photoreceptor cells. In addition, I demonstrated the pathogenesis of the development of serous retinal detachment and foveal cystoid spaces, depending on either retinal vascular hyperpermeability in the perifovea or the retinal vascular changes in the fovea or parafovea.
Finally, we applied self-organizing map for the analyses of multi-dimensional data, and showed novel associations and dissociations of OCT findings or parameters, and proposed a novel classification of morphological patterns in dmabetic macular edema
|
Research Products
(33 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] Association between hyperreflective foci in the outer retina, status of photoreceptor layer, and visual acuity in diabetic macular edema2012
Author(s)
Uji A, Murakami T, Nishijima K, Akagi T, Horii T, Arakawa N, Muraoka Y, Ellabban AA, Yoshimura N
-
Journal Title
Am J Ophthalmol
Volume: 153(4)
Pages: 710-7
-
-
-
-
-
-
-
-
[Presentation] Association between Near Infrared Autofluorescence and Optical Coherence Tomography in Diabetic Macular Edema2013
Author(s)
Yoshitake S, Murakami T, Uji A, Ogino K, Unoki N, Horii T, Hata M, Arichika S, Nishijima K, Yoshimura N
Organizer
ARVO Meeting
Place of Presentation
Seattle, USA
Year and Date
20130000
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
