Investigation of the roles of Mrp4 in retinal angiogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791854
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kobe University
• Principal Investigator: KUSUHARA SENTARO 神戸大学, 医学(系)研究科(研究院), 助教 (40437463)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Ｍｒｐ４ / ＡＢＣトランスポーター / 網膜 / 血管新生 / 酸素誘発網膜症モデル

Outline of Final Research Achievements

This study showed Mrp4, an efflux transporter, is intricately associated with physiological retinal angiogenesis by regulating intracellular cAMP level. Additionally, as both the formation of avascular area and extraretinal neovascularization were exacerbated in Mrp4 knockout mice in an oxygen-induced retinopathy model, Mrp4 seems to have a suppressive role in pathological retinal angiogenesis. These results suggest that Mrp4 is a promising therapeutic target for neovascular retinal diseases.

Free Research Field

医師薬学