2014 Fiscal Year Final Research Report
Therapeutic potential of IL-10 producing regulatory T cells for refractory ocular inflammatory diseases
| Project/Area Number |
24791859
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
YOSHIMURA Takeru 九州大学, 医学(系)研究科(研究院), 研究員 (40625802)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 眼科学 / 免疫学 |
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| Outline of Final Research Achievements |
(1)Inflamed retina contains CD4-positive IL-10 producing cells. While IL-27 regulates Th17 infiltration, IL-35 suggested to produce IFN-γ from CD4-positive cells, which leads to Th1-induced anti-inflammatory mechanism. (2) EBI3, a subunit of IL-27/IL-35, induces Th1 response and CD4-positive IL-10 producing cells upon initial inflammation, which in turn inhibits Th1/Th17 response on late inflammatory phase presumably by increasing CD4-positive IL-10 producing cells.
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| Free Research Field |
免疫学
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