2013 Fiscal Year Final Research Report
Ocular innate immune response in TAX1BP1 deficient mice
| Project/Area Number |
24791861
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | TAX1BP1 / A20 / NF-κB / エンドトキシン誘発ぶどう膜炎 |
|---|
| Research Abstract |
A20 (TNFAIP3) and Tax1-binding protein 1 (TAX1BP1) are known as the negative regulator of the nuclear factor (NF-kB) pathway. The polymorphism of the A20 gene is genetically linked to numerous autoimmune diseases. There were no reports of the expression A20 and TAX1BP1 in the ocular inflammation. In this study, we firstly reported the A20 expresses during endotoxin-induced uveitis and TAX1BP1-knock out mice have severe ocular inflammation than wild mice. A20 and TAX1BP1 might be controlled to uveitis like other inflammatory diseases.
|
Research Products
(2 results)
-
[Journal Article] Commensal Microbiota Contributes to Chronic Endocarditis in TAX1BP1 Deficient Mice2013
Author(s)
Satoko Nakano, Emi Ikebe, Y oshiyuki Tsukamoto, Y an Wang, Takashi Matsumoto, Takahiro Mitsui, Takaaki Y ahiro, Kunimitsu Inoue, Hiroaki Kawazato, Aiko Y asuda, Kanako Ito, Shigeo Y okoyama, Naohiko Takahashi, Mitsuo Hori, Tatsuo Shimada, Masatsugu Moriyama, T oshiaki Kubota, Katsushige Ono, Wataru Fujibuchi, Kuan-T eh Jeang, Hidekatsu Iha, Akira Nishizono
-
Journal Title
DOI
-
