2014 Fiscal Year Final Research Report
PKC-delta targeted treatment of proliferative vitreoretinopathy
| Project/Area Number |
24791862
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 増殖硝子体網膜症 / PKC δ / TGF-β / RPE / Ⅰ型コラーゲン |
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| Outline of Final Research Achievements |
Proliferative vitreoretinopathy (PVR) is severe complication after surgery of rhegmatogenous retinal detachment. Proliferative membrane, which is formed in the vitreous cavity and on the inner or outer surfaces of the neural retina, causes of PVR. It is thought that retinal pigment epithelium (RPE) cells could contribute to formation of proliferative membrane through production of collagen. In this study, we focused on PKC-δ which specifically express in proliferative membrane and analyzed about role of PKC-δ on collagen production system in RPE cells. For in vitro experiment, human RPE cell line (ARPE-19) was used. As results, we clarified that PKC-δ increase the typeⅠ collagen production in ARPE-19 cells. We expect that our findings contribute to development of novel therapeutic medicine targeting PKC-δ for PVR.
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| Free Research Field |
眼科学
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