Three-dimensional mechanical simulation analysis of human crystalline lens aimed at developing new accommodative intraocular lens

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791872
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kitasato University
• Principal Investigator: KAWAMORITA Takushi 北里大学, 医療衛生学部, 講師 (80511899)
• Research Collaborator: SHIMIZU Kimiya 北里大学, 医学部・眼科学, 教授 ; SHOJI Nobuyuki 北里大学, 医療衛生学部・視覚機能療法学専攻, 教授 ; UOZATO Hiroshi 大阪人間科学大学, 人間科学部・医療福祉学科・視能訓練専攻, 教授 ; KAMIYA Kazutaka 北里大学, 医学部・眼科学, 准教授 ; AKIYAMA Takeshi サイバネット株式会社 ; AKIYAMA Takeshi サイバネット株式会社
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 調節性眼内レンズ / 水晶体 / 眼内レンズ / チン小帯 / 水晶体嚢 / 光学 / 力学 / 結像特性

Outline of Final Research Achievements

To develop new accommodative intraocular lens (IOL), we analyzed mechanical characteristic of human crystalline lens and Zinn’s zonule by using computer simulation software, and investigated physical property required for new accommodative IOL. The present study showed that site for attachment of Zinn’s zonule and physical property of lens capsule cause a large change in shape of crystalline lens. As to physical property required for new accommodative IOL of curvature change type, logarithm elastic coefficient was 5.0 Pa and under. These resutls could be useful for selection of subsistent material of accommodative IOL.

Free Research Field

医歯薬学