2013 Fiscal Year Final Research Report
To analyze the transport between the outer retina and the choroidal circulation in Age-related macular degeneration
| Project/Area Number |
24791876
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 網膜脈絡膜物質輸送 / 加齢黄斑変性 / fenestrae / 脈絡膜毛細血管 |
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| Research Abstract |
To analyze in vivo tracer transport through the murine choriocapillaris, cardiac or tail vein injection using dextran , NHS-Biotin or transferrin to wild mice was done. The leakage outside of the choriocapillaris was observed immediately after injection with NHS-Biotin. On the other hand, punctate staining pattern was observed using dextran (70KDa) or transferrin. These results suggested that transport of small molecule was fenestrae-dependent and that of large molecule was endocytosis-dependent.
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