2014 Fiscal Year Final Research Report
Gene Analysis and Neural Crest Stem Cell Transplant Therapy for Hirschsprung's disease and the Related disorders.
| Project/Area Number |
24791890
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 再生医療 / 神経堤細胞 / 小児難治性疾患 / 腸管運動不全 / 細胞移植治療 |
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| Outline of Final Research Achievements |
A lack of enteric ganglion cells is the main feature of Hirschsprung's disease (HSCR). Some patients were not fully recovered because of the long aganglionic segment. For the future transplantation therapy, the neural crest derived cell (NCC) is one of the bestcandidates which can give rise to the neural lineage cells.The transplanted cells were detected in the aganglonic segmenst of the gut for several months after operation and they showed the neural lineage differentiation. Only HSCR model mice from transplanted group showed an improvement of the bowel function.Transplanted NCCs survived and facilitated the improvement of the gut motility in the HSCR model. These results suggest that usefulness of the cell transplantation therapy for future HSCR treatment.
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| Free Research Field |
小児外科
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