Small bowl resection : Role of renin-angiotensin system

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791891
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatric surgery
• Research Institution: Juntendo University
• Principal Investigator: KOGA Hiroyuki 順天堂大学, 医学(系)研究科(研究院), 准教授 (30468574)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 短腸症候群 / アポトーシス

Outline of Final Research Achievements

This study attempted to further examine the downstream signaling factors in this system by blocking the action of angiotensin II (ATII), hypothesizing that this would lead to similar improvement of intestinal adaptation after SBR. . Because realtime PCR studies showed that only ATII receptor type 1a (ATII-1a) expression was significantly increased after SBR, compared to Sham mice. The apoptotic and proliferation signaling pathways were addressed by analysis of EC. SBR led to a significant increase in villus height and crypt depth. ATII treatment did not significantly change EC proliferation, but did significantly reduce EC apoptosis rates as compared to the nontreated SBR group. This study showed that the ATII-1a receptor may be of crucial importance for the modulation of intestinal EC apoptosis, and for regulating the post-resectional EC adaptive response.

Free Research Field

外科