Development of treatment for primary and secondary lymphedema

2013 Fiscal Year Final Research Report

• Project/Area Number: 24791898
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: HARA Hisako 東京大学, 医学部附属病院, 助教 (50624243)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: リンパ浮腫 / 特発性胸腹水

Research Abstract

We investigated the collecting lymphatic vessels of the human body histopahologically. The lymphatic vessels were taken during lymphatico-venous anastomosis (LVA) surgery, in which we trim redundant part. We found the changes in lymphatic endothelial cells, smooth muscle cells, and collagen fibers. Also, we examined and treated neonatal lymphatic pleural effusion and ascites, using indocyanine green lymphography and LVA.

Research Products

• [Journal Article] The effect of lymphatico-venous anastomosis for an intractable ulcer at the lower leg in a marked obese patient (2014)
  • Author(s): Mihara M, Hara H, Todokoro T, Seki Y, Iida T, Koshima I, Murai N
  • Journal Title: Microsurgery Volume: 34(1) Pages: 64-7
• [Journal Article] Local anesthesia for lymphaticovenular anastomosis (2014)
  • Author(s): Chan VS, Narushima M, Hara H, Yamamoto T, Mihara M, Iida T, Koshima I
  • Journal Title: Ann Plast Surg Volume: 72(2) Pages: 180-3
• [Journal Article] High-accuracy diagnosis and regional classification of lymphedema using indocyanine green fluorescent lymphography after gynecologic cancer treatment (2014)
  • Author(s): Mihara M, Hayashi Y, Hara H, Iida T, Narushima M, Yamamoto T, Todokoro T, Murai N, Koshima I
  • Journal Title: Ann Plast Surg Volume: 72(2) Pages: 204-8
• [Journal Article] Comparison of indocyanine green lymphographic findings with the conditions of collecting lymphatic vessels of limbs in patients with lymphedema (2013)
  • Author(s): Hara H, Mihara M, Seki Y, Todokoro T, Iida T, Koshima I
  • Journal Title: Plast Reconstr Surg Volume: 132(6) Pages: 1612-8
• [Journal Article] Lymphoedema caused by idiopathic lymphatic thrombus (2013)
  • Author(s): Hara H, Mihara M, Seki Y, Koshima I
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: 66(12) Pages: 1780-3
• [Journal Article] Minimally invasive multiple lymphaticovenular anastomosis at the ankle for the prevention of lower leg lymphedema (2013)
  • Author(s): Onoda S, Todokoro T, Hara H, Azuma S, Goto A
  • Journal Title: Microsurgery
• [Journal Article] Treatment of hand lymphedema with free flap transfer and lymphangiogenesis analysis after hand replantation using indocyanine green (ICG) lymphography and histological analysis (2013)
  • Author(s): Mihara M, Hara H, Araki J, Narushima M, Iida T, Koshima I
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: 66(11) Pages: e338-40
• [Journal Article] Predictive Lymphatic Mapping : A Method for Mapping Lymphatic Channels in Patients With Advanced Unilateral Lymphedema Using Indocyanine Green Lymphography (2013)
  • Author(s): Mihara M, Seki Y, Hara H, Iida T, Oka A, Kikuchi K, Narushima M, Haragi M, Furniss D, Hin-Lun L, Mitsui K, Murai N, Koshima I
  • Journal Title: Ann Plast Surg
• [Journal Article] Effective treatment of pelvic lymphocele by lymphaticovenular anastomosis (2013)
  • Author(s): Todokoro T, Furniss D, Oda K, Kawana K, Narushima M, Mihara M, Kikuchi K, Hara H, Yano T, Koshima I
  • Journal Title: Gynecol Oncol Volume: 128(2) Pages: 209-14
• [Journal Article] Pathological steps of cancer-related lymphedema : histological changes in the collecting lymphatic vessels after lymphadenectomy (2013)
  • Author(s): Mihara M, Hara H, Hayashi Y, Narushima M, Yamamoto T, Todokoro T, Iida T, Sawamoto N, Araki J, Kikuchi K, Murai N, Okitsu T, Kisu I, Koshima I
  • Journal Title: PLoS One Volume: 7(7),8(5) Pages: e41126
  • DOI: 10.1371/journal.pone.0041126.Epub2012Jul24.Erratumin:PLoSOne
• [Journal Article] Presence of thoracic duct abnormalities in patients with primary lymphoedema of the extremities (2012)
  • Author(s): Hara H, Mihara M, Okuda I, Hirota A, Narushima M, Iida T, Yamamoto T, Todokoro T, Koshima I
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: 65(11) Pages: e305-10
• [Journal Article] Low-invasive lymphatic surgery and lymphatic imaging for completely healed intractable pudendal lymphorrhea after gynecologic cancer treatment (2012)
  • Author(s): Mihara M, Hara H, Narushima M, Mitsui K, Murai N, Koshima I
  • Journal Title: J Minim Invasive Gynecol Volume: 19(5) Pages: 658-62
• [Journal Article] Antegrade and retrograde lymphatico-venous anastomosis for cancer-related lymphedema with lymphatic valve dysfuction and lymphatic varix (2012)
  • Author(s): Mihara M, Hara H, Iida T, Todokoro T, Yamamoto T, Narushima M, Tashiro K, Murai N, Koshima I
  • Journal Title: Microsurgery Volume: 32(7) Pages: 580-4
• [Journal Article] Scarless lymphatic venous anastomosis for latent and early-stage lymphoedema using indocyanine green lymphography and non-invasive instruments for visualising subcutaneous vein (2012)
  • Author(s): Mihara M, Hara H, Kikuchi K, Yamamoto T, Iida T, Narushima M, Araki J, Murai N, Mitsui K, Gennaro P, Gabriele G, Koshima I
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: 65(11) Pages: 1551-8
• [Presentation] 新生児の特発性リンパ性胸腹水に対する new strategy (2013)
  • Author(s): 原尚子
  • Organizer: 第54回脈管学会総会
  • Year and Date: 2013-10-10
• [Presentation] 産婦人科領域の腹部リンパ疾患に対する新たな る ア プ ロ ー チ ~ Supermicrosurgeryを用いたリンパ管静脈吻合術~ (2013)
  • Author(s): 原尚子
  • Organizer: 第66回日本産婦人科学会学術講演会
  • Year and Date: 2013-05-12
• [Presentation] ICG 検査で「集合リンパ管の性状」を透視する ~NECST 分類~ (2013)
  • Author(s): 原尚子
  • Organizer: 第56回日本形成外科学会総会・学術集会
  • Year and Date: 2013-04-05
• [Presentation] Diagnostic and therapeutic approaches for neonatal idiopathic peritoneal or pleural effusion (2012)
  • Author(s): Hisako Hara
  • Organizer: Pacific Federation of Societies for Reconstructive Microsurgery
  • Year and Date: 2012-10-07
• [Book] リンパ管静脈吻合 (2013)
  • Author(s): ORTHOPEDIC SURGERY
  • Total Pages: 190-193
  • Publisher: 克誠堂出版