2013 Fiscal Year Final Research Report
The evaluation of Decellularized vessels for its practical use
| Project/Area Number |
24791904
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
TAKASU Hiroyuki 神戸大学, 医学部附属病院, 特定助教 (40566022)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 再生医学 / 再生型小口径人工血管 |
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| Research Abstract |
We have been developed decellularizing methods of tissues with hyper osmotic solutions. We have applied this methods for small diameter vessels and transplanted to rat model. In this study, we evaluated the decelularized vessels for its physiological property after transplantation, application of further smaller diameter, re-innervation, and preservation. On the result, patency of transplanted small diameter (1mm of diameter) vessels for longterm was obtained. And also, the translated decellularized vessels after the preservation with freeze-dry method showed patency. In addition, on the immunohistochemical study, the innovation of axon for its adventitia was confirmed and physiological property was observed with wire-myograph system.
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