2013 Fiscal Year Final Research Report
regeneration of lymph duct in rat lymphedema model
| Project/Area Number |
24791905
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
KOSAKA Jun 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (40243216)
KIMATA Yoshihiro 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50392345)
SUAMI Hiroo M.D.Anderson Cancer Center
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | リンパ浮腫 / リンパ管再生 |
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| Research Abstract |
The purpose of this study is to elucidate the process of regeneration of lymphatic system. We developed the replantation model in rat hind limb. The regeneration process was observed by microinjection with hydrogen peroxide and a blue ink or by fluorescence lymphangiography with ICG. The regeneration started from 5 days after the operation with growth of capillary lymph duct. Histological examination revealed that the number of signed lymph duct in superficial layer (skin and subcutaneous tissue layer) significantly increased in the process of regeneration. This increase persisted at least through 14 days after the operation.
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