2013 Fiscal Year Final Research Report

Elucidation of the role of Prostaglandin D synthase in sepsis patients with atherosclerosis and establishment of therapeutic strategy for sepsis

Research Project

Project/Area Number	24791935
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Emergency medicine
Research Institution	Shiga University of Medical Science
Principal Investigator	YAMANE Tetsunobu 滋賀医科大学, 医学部, 助教 (50464194)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	敗血症 / プロスタグランジンD合成酵素 / L-PGDS / 血液浄化法 / PDF
Research Abstract	We examined the serum Lipocalin-type prostaglandin D synthase (L-PGDS) level in critically ill patients admitted to our ICU. The serum L-PGDS level was higher in the sepsis patients compared with the non-sepsis patients. The serum L-PGDS level was correlated with DIC score, numbers of SIRS points, creatinine, lactate, D-dimer, Log IL-6 and Log IL-10. The sever sepsis patients received the blood purification therapy, and the serum L-PGDS level decreased significantly. There was no difference in serum L-PGDS level decrease rate when comparing CHDF therapy and PDF therapy. However, we couldn't treat enough amount of patients with blood purification therapy in this study, we will continue to evaluate the association between the serum L-PGDS level and blood purification therapy.

(3 results)