2013 Fiscal Year Final Research Report
Development of a novel strategy for heatstroke via the cholinergic anti-inflammatory pathway
| Project/Area Number |
24791938
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
OGURA Hiroshi 大阪大学, 医学系研究科, 准教授 (70301265)
MATSUMOTO Naoya 大阪大学, 医学部附属病院, 助教 (50359808)
IMAMURA Yukio 京都大学, 医学系研究科, 研究員 (90447954)
NAKAGAWA Junichiro 大阪大学, 医学部附属病院, 医員 (60597508)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | コリン作動性抗炎症経路 / 迷走神経刺激 / 熱中症 / 全身性炎症反応症候群 |
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| Research Abstract |
This study was performed to gain insights into novel therapeutic approaches for the treatment of heatstroke. We evaluated whether electrical vagus nerve stimulation (VNS) via the cholinergic anti-inflammatory pathway attenuates severe heatstroke, which induces a systemic inflammatory response. Seven-day mortality improved significantly in the VNS-treated group versus control group. Electrical VNS significantly suppressed induction of pro-inflammatory cytokines. Immunohistochemical analysis revealed that VNS treatment attenuated infiltration of inflammatory cells in lung and spleen. Interestingly, most cells with increased CD11b positivity in response to heat stress did not express a7 nicotinic acetylcholine receptor in the spleen. These data indicate that electrical VNS modulated cholinergic anti-inflammatory pathway abnormalities induced by heat stress, and this protective effect was associated with improved mortality.
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