Establishment of synbiotic therapy in severe sepsis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791939
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Osaka University
• Principal Investigator: YAMADA Tomoki 大阪大学, 医学部附属病院, 医員 (40623434)
• Research Collaborator: OGURA Hiroshi 大阪大学, 医学系研究科, 准教授 (70301265) ; SHIMIZU Kentaro 大阪大学, 医学部附属病院, 助教 (60379203)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: シンバイオティクス / プロバイオティクス / 敗血症 / RCT / 腸内細菌叢 / 短鎖脂肪酸

Outline of Final Research Achievements

The gut is an important target organ for injury after severe insults. We reported that gut microbiota and gut environment deteriorated in patients with severe systemic inflammatory response syndrome (SIRS) and that count of fecal microbiota and concentrations of fecal short-chain fatty acids (SCFAs) in these patients were significantly lower than those in healthy volunteers over a 6-week period. Furthermore, the gut flora was significantly altered in patients with sepsis, especially in non-survivors.
We evaluate if synbiotics therapy can maintain the gut microbiota and environment in patients with severe sepsis. There were significant differences between the synbiotics and no-synbiotics groups by the analysis of changes over time in number of total bacteria, Bifidobacterium, and Lactobacillus, and concentration of acetate and butylate. But there was no significant difference between the two groups about infectious complications and outcome.

Free Research Field

救急・集中治療医学、栄養管理