2014 Fiscal Year Final Research Report
The role of fibrocytes in oral area diseases
| Project/Area Number |
24791981
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
IBI MIHO 岩手医科大学, 薬学部, 助教 (30609665)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | fibrocyte / TMJ / inflammatory cytokines |
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| Outline of Final Research Achievements |
The aim of our research is to clarify whether fibrocytes participate in fibrous adhesion in temporomandibular joint (TMJ). For in vivo imaging of fibrocytes homing to TMJ tissues, we isolated adhesive mononuclear cells containing fibrocytes from bone marrows of fluorescent transgenic mice and administered monosodium iodoacetate into the upper compartment of mouse TMJ in order to generate a mouse model of TMJ osteoarthritis. Moreover, we gained fibroblast-like cells from TMJ tissues and showed the possibility that fibrocytes were homed to inflamed TMJ sites by migratory factors secreted from TMJ tissues stimulated with inflammatory cytokines.
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| Free Research Field |
口腔生化学 細胞生物学
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