2013 Fiscal Year Final Research Report
The role of hemoglobin receptor protein from Porphyromonas gingivalis on periodontitis
| Project/Area Number |
24791999
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Okayama University |
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Principal Investigator |
NAKAYAMA Masaaki 岡山大学, 医歯(薬)学総合研究科, 助教 (10579105)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 歯周病原細菌 / 歯周炎 / シグナル伝達 / 病原因子 |
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| Research Abstract |
In this study, we attempted to clarify about the function of hemoglobin receptor (HbR) protein from Porphyromonas gingivalis on the host epithelial cells and the relationship with inflammation in the periodontal diseases. Using gingival epithelial cell line Ca9-22 and primary gingivali epithelial cells, HbR protein induce interleukin-8 within at least 3 h after stimulation. Moreover, we revealed the molecular mechanisms by which HbR protein induced IL-8 production through the activation of p38/CREB and Erk1/2/ATF-2, NF-kB Therefore, these results led us to the possibility that HbR protein is associated with periodontitis by innate immun responses.
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Research Products
(22 results)
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[Journal Article] Interweaving MicroRNAs and Proinflammatory Cytokines in Gastric Mucosa with Reference to H. pylori Infection2012
Author(s)
Hajime Isomoto, Kayoko Matsushima, Naoki Inoue, Tomayoshi Hayashi, Toshiyuki Nakayama, Masaki Kunizaki, Shigekazu Hidaka, Masaaki Nakayama, Junzo Hisatsune, Masahiro Nakashima, Takeshi Nagayasu, Kazuhiko Nakao, and Toshiya Hirayama
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Journal Title
Journal of Clinical Immunology
Volume: 32(2)
Pages: 290-299
DOI
Peer Reviewed
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