2013 Fiscal Year Final Research Report
Crosstalk between salivary gland chronic inflammation and saturated fatty acids in plasma
| Project/Area Number |
24792001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | シェーグレン症候群 / 唾液腺 / 遊離脂肪酸 |
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| Research Abstract |
Elevated concentrations of free fatty acids (FFAs) such as palmitate (Pal) are implicated in the mechanism underlying obesity-associated inflammation and apoptosis. The clinical significance of FFAs in patients with primary Sjogren's syndrome (pSS), which is an autoimmune disease characterized by destruction of salivary gland epithelial cells, is little studied, even though there is evidence linking sicca syndrome with dyslipidemia and diabetes. Here, we show that Pal induces IL-6 production, alpha-fodrin degradation which is an important auto-antigen in pSS, and apoptosis in salivary gland epithelial cell, but not in other types of epithelial cells. These results suggest that Pal may exacerbate the pathogenesis of pSS in salivary glands.
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