The analysis of developing metastasis induced by cancer treatment

2014 Fiscal Year Final Research Report

• Project/Area Number: 24792004
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: University of the Ryukyus
• Principal Investigator: KINA Shinichiro 琉球大学, 医学(系)研究科(研究院), 助教 (40422422)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 抗癌剤耐性

Outline of Final Research Achievements

For decades, platinum drugs have been the mainstay of cancer treatment. However, over time, drug resistance develops, leaving few treatment options. Here we show that platelet-derived growth factor receptor (PDGF αreceptor)　plays a key role in chemotherapy resistance by upregulating HGF（Hepatocyte Growth Factor) receptor protein(Met). Chemotherapy induced Met protein expression in cancer cells. Chemotherapy-induced Met protein upregulation is inhibited by PDGF receptor inhibitor Imatinib. Chemotherapy induced PDGF receptor tyrosine phosphorylation. PDGF　receptor inhibition significantly increased chemotherapy-induced cancer death. PDGF receptor inhibitors are widely used in clinical settings, suggesting that the clinical translation of our findings could reduce the suffering of people from drug resistance.

Free Research Field

腫瘍分子生物学