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2013 Fiscal Year Final Research Report

Ectopic expression of HMGA2 in oral carcinomas and tumor progression

Research Project

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Project/Area Number 24792012
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionThe Nippon Dental University

Principal Investigator

MAEDA Genta  日本歯科大学, 生命歯学部, 助教 (80434140)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords癌 / EMT / HMGA2
Research Abstract

HMGA2 is expressed typically in the mesenchymal cell before its differentiation, but it is also expressed in tumors of epithelium. Ectopic expression of High mobility group-A2 (HMGA2) in epithelial tumor cell is a deriver of mesenchymal transition (EMT), which has been implicated in the achievement of metastatic characters in tumor cells. Those date demonstrate that HMGA2 combined the Zic1 promoter site and controlled target gene expression in oral tumor cells, thereby inducing invasion and metastasis of human epithelial cancers.

  • Research Products

    (5 results)

All 2013 2012

All Journal Article (4 results) Presentation (1 results)

  • [Journal Article] Concomitant loss of p120-catenin and β-c atenin membrane expression and oral carcino ma progression with E-cadherin reduction2013

    • Author(s)
      Sasa ya K, Sudo H, Maeda G, Kawashiri S, Imai K
    • Journal Title

      PLoS One

      Volume: 6 Pages: 8

  • [Journal Article] Mutational analysis of HRAS and KRAS genes in oral carcinoma cell lines2012

    • Author(s)
      Maemoto S, Yumoto M, Ibata M, Torizuka S, Ozawa N, Tatsumi S, Hashido M, Morikawa M, Ma eda G, Imai K
    • Journal Title

      Odontology

      Volume: 100(2) Pages: 149-55

  • [Journal Article] Pericyte depletion results in hypoxia-assoc iated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway2012

    • Author(s)
      Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R
    • Journal Title

      Canc er Cell

      Volume: 21(1) Pages: 66-81

  • [Journal Article] Progression of oral squamous cell carcino ma accompanied with reduced E-cadherin exp ression but not cadherin switch2012

    • Author(s)
      Hashimoto T, Soeno Y, Maeda G, Taya Y, Aoba T, Nasu M, Kawashiri S, Imai K
    • Journal Title

      PLoS One

      Volume: 7

  • [Presentation] 日本歯科基礎医学界2012

    • Author(s)
      前田 元太
    • Organizer
      血管周皮細胞欠失による上皮間葉移行と癌転移はMet シグナルにより制御される.
    • Place of Presentation
      奥羽大学
    • Year and Date
      2012-09-15

URL: 

Published: 2015-06-25  

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