2013 Fiscal Year Final Research Report
Ectopic expression of HMGA2 in oral carcinomas and tumor progression
| Project/Area Number |
24792012
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
MAEDA Genta 日本歯科大学, 生命歯学部, 助教 (80434140)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 癌 / EMT / HMGA2 |
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| Research Abstract |
HMGA2 is expressed typically in the mesenchymal cell before its differentiation, but it is also expressed in tumors of epithelium. Ectopic expression of High mobility group-A2 (HMGA2) in epithelial tumor cell is a deriver of mesenchymal transition (EMT), which has been implicated in the achievement of metastatic characters in tumor cells. Those date demonstrate that HMGA2 combined the Zic1 promoter site and controlled target gene expression in oral tumor cells, thereby inducing invasion and metastasis of human epithelial cancers.
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[Journal Article] Pericyte depletion results in hypoxia-assoc iated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway2012
Author(s)
Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R
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Journal Title
Canc er Cell
Volume: 21(1)
Pages: 66-81
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