2013 Fiscal Year Final Research Report
Effects of ions released from dental cements on osteoblast-like cells
| Project/Area Number |
24792023
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
KIBA Wakako 大阪大学, 歯学研究科(研究院), 招聘教員 (10523087)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 保存修復学 / 歯科用修復材料 / 骨芽細胞 |
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| Research Abstract |
To examine each of BO33-, Sr2+, Al3+, Na+, SiO32-, and F-, we succeed to make solutions with same counter ions such as H3BO3, Sr(NO3)2, Al(NO3)3, Na2SiO3, and NaF at the neutral pH. MC3T3-E1 cells were seeded and each solution was added. Cell proliferation was examined by MTT assay. Significant increase in the cell number was obtained by Sr(NO3)2. Culture with H3BO3 for 3 days and NaF demonstrated inhibition of cell proliferation in a dose-dependent manner. MC3T3-E1 cells proliferate well in the presence of Sr(NO3)2, indicating the positive effects of Sr2+ ion on osteoblasts. On the contrary, BO33- and F- appear to have negative influences on osteoblastic proliferation.
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