2013 Fiscal Year Final Research Report
Involvement of plasmin-induced COX-2 expression and PKC activation.
| Project/Area Number |
24792039
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
KAMIO Naoto 日本大学, 松戸歯学部, 助教 (10508774)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 歯髄 / 細胞・組織 / 炎症 / プラスミン / シグナル伝達 |
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| Research Abstract |
The purpose of this study was to clarify the involvement of Plasmin-induced COX-2 and PKC activation. As a result, plasmin evoked intracellular Ca2+ mobilization and COX-2 expression, which consisted of Ca2+ release from the intracellular pools and Ca2+ entry from extracellular sites in human dental pulp cells. Further, PKC signaling is also involved in COX-2 production by Plasmin
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