Clarification of dentinogenesis and its relationship with Wnt signaling during pulpal regeneration

2014 Fiscal Year Final Research Report

• Project/Area Number: 24792043
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: MUTO NORIKO 神奈川歯科大学, 歯学研究科(研究院), 講師 (40510433)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Wnt / 歯髄 / 歯学 / 免疫学 / シグナル伝達 / 発生学

Outline of Final Research Achievements

The present study clarified that tooth replantation/transplantation induced the apoptosis of odontoblasts and the subsequent differentiation of dental pulp stem cells (DPSCs) into the odontoblasts following active cell proliferation, whereas bone formation occurred if the DPSCs degenerated. Due to the migration of non-inherent pulpal cells into the pulp chamber and the transient increase of Wnt signaling in the perivascular niche of the center of pulp tissue, suggesting the involvement of Wnt signal for the maintenance of DPSCs. Thus, dynamic donor-host or pulp-periodontal tissue interactions induce the drastic changes in pulp cell populations following tooth replantation/transplantation.

Free Research Field

歯内療法学